Endocrine Abstracts

Introduction: Many studies have shown that cigarette smoking exerts multiple effects on the thyroid gland. Smoking seems to induce changes in thyroid function tests, like a left-shift in serum TSH level that is more apparent in iodine-deficient subjects and increase in thyroid hormones. We describe the effect of an intensive thyroxine intravenous treatment in severe hypothyroid patients and the results depending on their smoking status.Material and metho...

Introduction: The NETTER 1 trial resulted in markedly longer progression-free survival (PFS), with preliminary evidence of an overall survival benefit. We report the results of PFS and safety of (177Lu)-DOTATATE in patients treated in our hospital between 2014 and 2016.Methods: Transversal and descriptive study of seven patients with advanced, progressive, somatostatin receptor-positive tumors who had received previous treatments. All of them were treate...

Introduction: Nivolumab is an anti-programmed cell death-1 monoclonal antibody approved for the treatment of metastatic malignant melanoma. Several endocrine disorders have been reported as immune-related adverse effects. However, nivolumab-induced hypophysitis has a lower incidence than ipililumab.Case report: A 69-years old man with metastatic melanoma started to receive nivolumab. Ten weeks after the first cycle of nivolumab he presented hyperthyroidi...

Introduction: Bilateral sampling of the inferior petrosal sinuses is an accurate test to diagnose Cushing’s disease and distinguish it with the ectopic ACTH syndrome. The aim of the study was to review the petrosal sinus samplings carried out during last 10 years in our hospital.Methods and material: The medical histories of patients admitted for suspected Cushing’s disease in the last 10 years (from 2005 till 2015) were reviewed. There were se...

Introduction: Hyperthecosis ovarian is a type of hyperandrogenism and severe insulin resistance, usually found in postmenopausal women.Case Report: This case is about a 12 year-old girl who came to our hospital because of a rapidly progressive virilization. She had no medical history. For the previous 10 months, she had felt progressive growth of terminal hair in androgen-dependent areas, abundant hair loss, facial acne and voice changes. Axilarche and p...

Introduction: Graves’ and Hashimoto’s diseases are considered two extremes of the same autoimmune thyroid disease. Spontaneous conversion from hypothyroidism to hyperthyroidism is uncommon. On the other hand, Graves’ disease typically improves during pregnancy and worsens after delivery. We describe a patient with an unusual course of thyroid disease during pregnancy.Case report: An 33-year-old woman, with a two-year history of hypothyroid...

Background: Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances, in particular from pre-diabetes and diabetes. Conflicting results currently exists on the relationship between vitamin D and glucose metabolism. Hence, the aim of our study was to investigate the association of 25-hydroxyvitamin D (25(OH)D) levels and glucose tolerance in PCOS women.Methods: Cross-sectional study including 23 PCOS patients (mean age 27 ...

Background: Obesity has been associated with low levels of 25-hydroxyvitamin D (25(OH)D). This could be explained by a low dietary intake, reduced sun exposure or less biodisponibility because of its arrest in the fat mass. The main objective is to study the prevalence of 25(OH)D deficiency in premenopausal obese women.Methods: Aleatory sample of 100 morbidly obese patients. Selection criteria were: women, premenopausal, Caucasian. Patient with diabetes ...

Aim: Non-alcoholic fatty liver disease (NAFLD) and type 2 Diabetes (T2D) are common conditions that frequently co-exist. Studies have shown an increase likelihood of micro and macrovascular complications in this population, as well, as an increased risk of developing more severe forms of liver disease. The aim of this study was to identify diabetic complications in patients with both diseases and search for an association with liver stiffness assessed by Liver Elastography (LE...

Introduction: The NETTER 1 trial resulted in markedly longer progression-free survival (PFS), with preliminary evidence of an overall survival benefit. We report the results of PFS and safety of (177Lu)-DOTATATE in patients treated in our hospital between 2014 and 2017.Methods: Transversal and descriptive study of 22 patients with advanced, progressive, somatostatin receptor-positive tumors who had received previous treatments. All of them were treated w...